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About Phrontline
Dedicated to developing innovative antibody-drug conjugates (ADCs) to address unmet medical needs in oncology

Phrontline Biopharma is dedicated to developing innovative antibody-drug conjugates (ADCs) to address unmet medical needs in oncology. We specialize in engineering dual-targeting antibodies to enhance the precision and efficiency of payload delivery. In parallel, our proprietary dual-payload platforms are designed to overcome drug resistance and extend treatment response, inspired by the clinical success of combination chemotherapy. Guided by science and driven by innovation, Phrontline is committed to becoming a leading global biopharmaceutical company focused on delivering next-generation frontline cancer therapies.

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History
2022

2022-01-11 Company founded

2022-03-10 Secured Angel Round financing from Med-Fine Capital

2023

2023-12-25  Secured Pre-A Round financing from Decheng Capital . Initiated IND-enabling study of TJ101.

2024

2024-12-27 Validate dual linker payload platform 

2025

2025-01-06 Initiated IND-enabling study of TJ102

2025-04-24 TJ101 received IND clearance by FDA

Our Pipeline

Program

Targets

Fomats

Indication

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ101

EGFR XB7H3

Bispecific ADC

NSCLC, HNSCC, etc

TJ102

FRa x CDH6

Bispecific dual payload ADC

OC, RCC etc

TJ106

HER2 x HER2

Bispecific dual payload ADC

Breast Cancer (pan-Her2)

TJ108

EGFR x cMet

Bispecific dual payload ADC

NSCLC etc

TJ109

EGFR x HER3

Bispecific dual payload ADC

NSCLC etc

TJ111

Trop2 x Nectin4

Bispecific dual payload ADC

Urothiel cancer

TJ101

EGFR XB7H3

Bispecific ADC

NSCLC, HNSCC, etc

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ102

FRa x CDH6

Bispecific dual payload ADC

OC, RCC etc

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ106

HER2 x HER2

Bispecific dual payload ADC

Breast Cancer (pan-Her2)

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ108

EGFR x cMet

Bispecific dual payload ADC

NSCLC etc

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ109

EGFR x HER3

Bispecific dual payload ADC

NSCLC etc

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

TJ111

Trop2 x Nectin4

Bispecific dual payload ADC

Urothiel cancer

Target Validation

PCC

IND

Clinical Ⅰ/Ⅱ/Ⅲ

Market

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News
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