Synergy in the Tumor Microenvironment (SynTume™) is achieved when two distinct mechanisms of action (MOAs) are simultaneously engaged through the release of dual payloads from our proprietary dual-linker payload ADCs (DLP-ADCs). These ADCs are specifically designed to accumulate in the tumor microenvironment (TME), where the linkers are selectively cleaved by TME-associated enzymes or pH conditions. This targeted release enables two complementary payloads to act in concert, enhancing anti-tumor efficacy through synergistic cell killing mechanisms.